Drug General Information
Drug ID
D04FDN
Former ID
DNCL002263
Drug Name
Palifosfamide
Synonyms
ZIO-201
Drug Type
Small molecular drug
Indication Soft tissue sarcoma [ICD9: 171; ICD10:C00-D49] Phase 2 [524236]
Company
ZIOPHARM Oncology
Structure
Download
2D MOL

3D MOL

Formula
C4H11Cl2N2O2P
Canonical SMILES
C(CCl)NP(=O)(NCCCl)O
InChI
1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
InChIKey
BKCJZNIZRWYHBN-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) DNMT1 Target Info Inhibitor [531674]
KEGG Pathway Cysteine and methionine metabolism
Metabolic pathways
MicroRNAs in cancer
Pathway Interaction Database Regulation of retinoblastoma protein
PathWhiz Pathway Methionine Metabolism
Reactome PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
DNA methylation
WikiPathways Trans-sulfuration and one carbon metabolism
Retinoblastoma (RB) in Cancer
One Carbon Metabolism
Trans-sulfuration pathway
References
Ref 524236ClinicalTrials.gov (NCT01808534) Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors. U.S. National Institutes of Health.
Ref 531674Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012 Feb;23(2):173-84.

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