Drug Information

Drug General Information
Drug ID
D04NAL
Former ID
DIB020276
Drug Name
LY314228
Synonyms
LY 314228; LY-314228
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539135]
Structure
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2D MOL

3D MOL
Formula
C20H24N4O3
InChI
InChI=1S/C20H24N4O3/c1-3-4-18-15(7-10-17(13(2)25)19(18)26)12-27-16-8-5-14(6-9-16)11-23-24-20(21)22/h5-11,26H,3-4,12H2,1-2H3,(H4,21,22,24)/b23-11+
InChIKey
TUXHQPAMNGTVLT-FOKLQQMPSA-N
PubChem Compound ID
9976312
PubChem Substance ID
14954102, 44027652, 48029719, 48254029, 78256778, 136351102
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [534232]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539135(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 181).
Ref 534232A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68.

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