Drug Information

Drug General Information
Drug ID
D04QKU
Former ID
DIB011780
Drug Name
RG-7090
Synonyms
RO-4917523; Antidepressant (oral), Hoffmann-La Roche; MGluR5 antagonist (depression/fragile X syndrome, oral), Roche
Drug Type
Small molecular drug
Indication Fragile X syndrome [ICD9: 332, 759.83; ICD10:F02.3, G20, Q99.2] Phase 2 [524162]
Company
F Hoffmann-La Roche Ltd
Structure
Download
2D MOL

3D MOL
Formula
C18H13ClFN3
Canonical SMILES
Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1c3ccc(F)cc3
InChI
1S/C18H13ClFN3/c1-12-17(8-3-14-9-10-21-18(19)11-14)22-13(2)23(12)16-6-4-15(20)5-7-16/h4-7,9-11H,1-2H3
InChIKey
UPZWINBEAHDTLA-UHFFFAOYSA-N
PubChem Compound ID
11438771
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Antagonist [544380]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 524162ClinicalTrials.gov (NCT01750957) A Study of RO4917523 in Pediatric Patients With Fragile X Syndrome. U.S. National Institutes of Health.
Ref 544380The challenges of clinical trials in fragile X syndrome. Psychopharmacology (Berl) 2014; 231(6): 1237-1250.

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