Drug Information

Drug General Information
Drug ID
D04QWE
Former ID
DAP000348
Drug Name
Levallorphan
Synonyms
Levallofano; Levallorphane; Levallorphanum; Levalorfano; Naloxiphan; Levallofano [DCIT]; Levallorphan [INN:BAN]; Levallorphane [INN-French]; Levallorphanum [INN-Latin]; Levalorfano [INN-Spanish]; Lorfan (TN); Ro-1-7700; N-Allyl-3-hydroxymorphinan; L-N-Allyl-3-hydroxymorphinan; Levo-3-hydroxy-N-allyl morphinan; (-)-3-Hydroxy-N-allylmorphinan; 17-Allylmorphinan-3-ol; 17-prop-2-en-1-ylmorphinan-3-ol
Drug Type
Small molecular drug
Indication Narcotic depression [ICD9: 304.9, 311; ICD10:F19.20, F32] Approved [538429], [542223]
Therapeutic Class
Antinarcotic Agents
Company
Hoffmann La Roche Inc
Structure
Download
2D MOL

3D MOL
Formula
C19H25NO
InChI
InChI=1S/C19H25NO/c1-2-10-20-11-9-19-8-4-3-5-16(19)18(20)12-14-6-7-15(21)13-17(14)19/h2,6-7,13,16,18,21H,1,3-5,8-12H2/t16-,18+,19+/m0/s1
InChIKey
OZYUPQUCAUTOBP-QXAKKESOSA-N
CAS Number
CAS 152-02-3
PubChem Compound ID
5359371
PubChem Substance ID
9281, 15492112, 37101782, 46505682, 48416164, 49992870, 50523311, 57371627, 123094338, 123105788, 128885811, 134222344, 134337659, 134973596, 137005182, 142971107, 144205558, 160963850, 163228304, 170465778, 178103784, 179296074, 198941341, 223440161, 226420585
Target and Pathway
Target(s) Neuronal acetylcholinereceptor subunit alpha-2 Target Info Antagonist [536781]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 538429FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010423.
Ref 542223(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7209).
Ref 536781Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.

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