Drug General Information
Drug ID
D05HQX
Former ID
DNC003874
Drug Name
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526504]
Structure
Download
2D MOL
Formula
C16H17N3O
Canonical SMILES
CCCCC1=C2C(=NC=CN2)NC1=C3C=CC(=O)C=C3
InChI
1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,17H,2-4H2,1H3,(H,18,19)
InChIKey
AYIIQABSVDIZSY-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) G1/S-specific cyclin E1 Target Info Inhibitor [526504]
Cyclin-A2 Target Info Inhibitor [526504]
Cell division protein kinase 2 Target Info Inhibitor [526504]
KEGG Pathway Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Hepatitis B
Measles
Pathways in cancer
Viral carcinogenesis
MicroRNAs in cancer
Prostate cancer
Small cell lung cancerhsa03030:DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
HTLV-I infectionhsa04068:FoxO signaling pathway
Progesterone-mediated oocyte maturation
Herpes simplex infection
Epstein-Barr virus infection
Small cell lung cancer
NetPath Pathway IL2 Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Cell cycle
Parkinson disease
p53 pathway
p53 pathway feedback loops 2P00059:p53 pathway
p53 pathway feedback loops 2
Pathway Interaction Database Signaling events mediated by PRL
E2F transcription factor network
mTOR signaling pathway
FOXM1 transcription factor network
BARD1 signaling events
PLK3 signaling events
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
p73 transcription factor network
ATR signaling pathway
IL2-mediated signaling events
FoxO family signaling
p53 pathway
Regulation of retinoblastoma protein
PathWhiz Pathway Nucleotide Excision Repair
Reactome E2F mediated regulation of DNA replication
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
p53-Dependent G1 DNA Damage ResponseR-HSA-113510:E2F mediated regulation of DNA replication
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Senescence-Associated Secretory Phenotype (SASP)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
G2 Phase
Orc1 removal from chromatin
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entryR-HSA-1538133:G0 and Early G1
Activation of ATR in response to replication stress
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet production
WikiPathways DNA Damage Response
ID signaling pathway
G1 to S cell cycle control
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Parkinsons Disease Pathway
Parkin-Ubiquitin Proteasomal System pathway
Signaling Pathways in Glioblastoma
TSH signaling pathway
Mitotic G1-G1/S phases
Cell Cycle
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
Androgen receptor signaling pathwayWP615:Senescence and Autophagy in Cancer
Mismatch repair
DNA Replication
EGF/EGFR Signaling Pathway
S Phase
Nifedipine Activity
Primary Focal Segmental Glomerulosclerosis FSGS
Nucleotide Excision Repair
Telomere Maintenance
Synthesis of DNA
Base Excision RepairWP707:DNA Damage Response
M/G1 Transition
Meiotic Recombination
Aryl Hydrocarbon Receptor
ATM Signaling Pathway
Spinal Cord Injury
Oncostatin M Signaling Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Regulation of DNA replication
Mitotic G2-G2/M phases
Factors involved in megakaryocyte development and platelet production
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
References
Ref 526504J Med Chem. 2003 Jan 16;46(2):222-36.Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.
Ref 526504J Med Chem. 2003 Jan 16;46(2):222-36.Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.

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