Drug Information

Drug General Information
Drug ID
D05MFO
Former ID
DNC004111
Drug Name
MDL-11939
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 3 [539169], [544618]
Structure
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2D MOL

3D MOL
Formula
C20H25NO
InChI
InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2
InChIKey
AXNGJCOYCMDPQG-UHFFFAOYSA-N
PubChem Compound ID
71781
PubChem Substance ID
6797184, 8194826, 14898173, 43128054, 47206247, 47359954, 47954521, 50064132, 50193113, 56311668, 57318359, 85210532, 85788118, 91746356, 103064544, 103077094, 103184480, 103918010, 104351286, 117612643, 126424413, 126678986, 127473340, 134221813, 134341316, 135030226, 135287998, 135650574, 135698212, 137239955, 137239956, 142572591, 143344450, 162022664, 162221881, 163108262, 179149554, 184536608, 184547728, 204369769, 223654227, 224897292, 226491673, 241181941, 241377505, 252345049
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [526959]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539169(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 186).
Ref 544618Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000314)
Ref 526959J Med Chem. 1992 Dec 25;35(26):4903-10.Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding.

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