Drug Information

Drug General Information
Drug ID
D05OFX
Former ID
DCL000858
Drug Name
Lacosamide
Synonyms
Erlosamide; Harkoseride; Vimpat; Erlosamide [INN]; Lacosamide [USAN]; ADD 234037; SPM 927; ADD-234037; SPM-927; SPM-929; Erlosamide, Vimpat, Lacosamide; Lacosamide (USAN/INN); (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-acetamido-N-benzyl-3-methoxypropanamide
Drug Type
Small molecular drug
Indication Convulsions [ICD9: 780.3; ICD10:R56.0] Approved [529941], [542497]
Epilepsy [ICD10:G40] Phase 4 [536934], [542497]
Painful diabetic neuropathy [ICD9: 250.6,338,780; ICD10:E10.4, E11.4, E13.4, G89, R52] Phase 3 [536934], [542497]
Therapeutic Class
Analgesics
Company
Schwarz Pharma
Structure
Download
2D MOL

3D MOL
Formula
C13H18N2O3
InChI
InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
InChIKey
VPPJLAIAVCUEMN-GFCCVEGCSA-N
CAS Number
CAS 175481-36-4
PubChem Compound ID
219078
PubChem Substance ID
9374274, 12015335, 14847708, 15196715, 30422445, 50069298, 51091636, 53505872, 57399840, 58107206, 99218530, 99298399, 99437053, 103245465, 104154565, 109693474, 113468551, 123121578, 124757118, 125163922, 126575044, 126624062, 126644682, 126667072, 126733504, 129508865, 134339319, 135141960, 135367753, 135697647, 135707761, 136895303, 136991060, 137237313, 137237672, 139113413, 152258417, 160647253, 160660621, 160826045, 162037520, 162188094, 163092695, 163589394, 164824528, 170466190, 172086321, 174006177, 174527897, 175266112
SuperDrug ATC ID
N03AX18
Target and Pathway
Target(s) Dihydropyrimidinase related protein 2 Target Info Modulator [529941]
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 536934Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. Epub 2008 Nov 12.
Ref 542497(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7472).
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.

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