Drug Information

Drug General Information
Drug ID
D05RAV
Former ID
DIB018415
Drug Name
[3H]SQ-29548
Synonyms
[3H]SQ-28053; [3H]SQ29548; [3H]-SQ29548
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539282]
Structure
Download
2D MOL
Formula
C21H29N3O4
InChI
InChI=1S/C21H29N3O4/c25-20(26)11-7-2-1-6-10-16-17(19-13-12-18(16)28-19)14-22-24-21(27)23-15-8-4-3-5-9-15/h1,3-6,8-9,16-19,22H,2,7,10-14H2,(H,25,26)(H2,23,24,27)/b6-1-/t16-,17+,18-,19+/m1/s1
InChIKey
RJNDVCNWVBWHLY-OQMICVBCSA-N
PubChem Compound ID
6437074
PubChem Substance ID
39341122, 53787742, 57367833, 80342077, 135270022, 135651068, 135651207
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [525673]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539282(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1985).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.

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