Drug Information

Drug General Information
Drug ID
D05UZY
Former ID
DIB018697
Drug Name
7-fluorochromone-2-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538799]
Structure
Download
2D MOL
Formula
C23H21FN2O5
InChI
InChI=1S/C23H21FN2O5/c24-15-2-3-17-18(27)11-22(31-20(17)10-15)23(28)25-16-5-7-26(8-6-16)12-14-1-4-19-21(9-14)30-13-29-19/h1-4,9-11,16H,5-8,12-13H2,(H,25,28)
InChIKey
FVFURMJFTAJXRH-UHFFFAOYSA-N
PubChem Compound ID
11539096
PubChem Substance ID
16641208, 23663088, 42657115, 50077116, 76216355, 103501289, 104078615, 135649860, 137960149, 228758948, 248630158
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [528492]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538799(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1303).
Ref 528492Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem. 2006 Nov 2;49(22):6569-84.

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