Drug Information

Drug General Information
Drug ID
D06BLF
Former ID
DNC007007
Drug Name
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528558]
Structure
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2D MOL

3D MOL
Formula
C8H12Br4
Canonical SMILES
C1CC(C(CC1C(CBr)Br)Br)Br
InChI
1S/C8H12Br4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h5-8H,1-4H2
InChIKey
PQRRSJBLKOPVJV-UHFFFAOYSA-N
PubChem Compound ID
18728
Target and Pathway
Target(s) Androgen receptor Target Info Inhibitor [528558]
mRNA of androgen receptor Target Info Inhibitor [528558]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04114:Oocyte meiosis
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP706:SIDS Susceptibility Pathways
Androgen receptor signaling pathway
References
Ref 528558J Med Chem. 2006 Dec 14;49(25):7366-72.Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist.
Ref 528558J Med Chem. 2006 Dec 14;49(25):7366-72.Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist.

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