Drug Information

Drug General Information
Drug ID
D06PVQ
Former ID
DIB018233
Drug Name
[3H]AF DX-384
Synonyms
[3H]AF-DX 384
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540501]
Formula
C27H38N6O2
InChI
InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)
InChIKey
MZDYABXXPZNUCT-UHFFFAOYSA-N
PubChem Compound ID
119357
PubChem Substance ID
6900592, 7979245, 10238457, 15332333, 29300255, 47657113, 48179722, 48179723, 50070805, 52134134, 57339454, 85211315, 85788649, 91746243, 103188375, 104408137, 126434298, 128668861, 131342475, 135651133, 135698249, 160845571, 162023063, 162219994, 178100307, 224909737, 235187282, 241182347, 241375371, 252559467
Target and Pathway
Target(s) Muscarinic receptor Target Info Antagonist [530102]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540501(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 368).
Ref 530102Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J Pharmacol Exp Ther. 1991 Nov;259(2):601-7.

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