Drug General Information
Drug ID
D06XEL
Former ID
DCL000106
Drug Name
DG051
Drug Type
Small molecular drug
Indication Myocardial infarction [ICD9: 410; ICD10:I21, I22] Discontinued in Phase 2 [541672], [548272]
Company
DeCODE genetics
Structure
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2D MOL

3D MOL

Formula
C21H24ClNO4
InChI
InChI=1S/C21H24ClNO4/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25/h5-12,17H,1-4,13-15H2,(H,24,25)/t17-/m0/s1
InChIKey
PVCTYSQBVIGZRU-KRWDZBQOSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Leukotriene A-4 hydrolase Target Info Inhibitor [536080], [536517]
BioCyc Pathway Leukotriene biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 541672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6548).
Ref 548272Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024010)
Ref 536080Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial. JAMA. 2005 May 11;293(18):2245-56.
Ref 536517BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8.

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