Drug Information

Drug General Information
Drug ID
D07JJC
Former ID
DIB014804
Drug Name
DPC-684
Synonyms
N-(3-Fluorobenzyl)glycyl-N-[3-[N-(4-aminophenylsulfonyl)-N-isobutylamino]-1(S)-benzyl-2(R)-hydroxypropyl]-3-methyl-L-valinamide
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 1 [547253]
Structure
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2D MOL

3D MOL
Formula
C35H48FN5O5S
Canonical SMILES
CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)C(C(C)(C)C)NC(=O)CNCC2=<br />CC(=CC=C2)F)O)S(=O)(=O)C3=CC=C(C=C3)N
InChI
1S/C35H48FN5O5S/c1-24(2)22-41(47(45,46)29-16-14-28(37)15-17-29)23-31(42)30(19-25-10-7-6-8-11-25)39-34(44)33(35(3,4)5)40-32(43)21-38-20-26-12-9-13-27(36)18-26/h6-18,24,30-31,33,38,42H,19-23,37H2,1-5H3,(H,39,44)(H,40,43)/t30-,31+,33+/m0/s1
InChIKey
IXZYCIFRVZKVRJ-RKKDRKJOSA-N
PubChem Compound ID
464031
PubChem Substance ID
616509, 10304499, 14912855, 14912856, 75185549, 109737802, 135346490, 141982177, 162845361, 247598710
Target and Pathway
Target(s) HIV protease Target Info Inhibitor [526167], [551871]
References
Ref 547253Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014481)
Ref 526167DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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