Drug Information
Drug General Information | |||||
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Drug ID |
D07LUJ
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Former ID |
DNC007423
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Drug Name |
URSOLIC ACID
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [530285] | ||
Structure |
Download2D MOL |
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Formula |
C30H48O3
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Canonical SMILES |
CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)<br />C(=O)O
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InChI |
1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
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InChIKey |
WCGUUGGRBIKTOS-GPOJBZKASA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | Target Info | Inhibitor | [530656] | |
Phospholipase A2 | Target Info | Inhibitor | [527616] | ||
DNA polymerase | Target Info | Inhibitor | [525684] | ||
Glycogen phosphorylase, muscle form | Target Info | Inhibitor | [530285] | ||
mRNA of Protein tyrosine phosphatase-1B | Target Info | Inhibitor | [530454] | ||
BioCyc Pathway | PhospholipasesPWY-5941:Glycogenolysis | ||||
KEGG Pathway | Steroid hormone biosynthesis | ||||
Metabolism of xenobiotics by cytochrome P450 | |||||
Metabolic pathways | |||||
Chemical carcinogenesishsa00564:Glycerophospholipid metabolism | |||||
Ether lipid metabolism | |||||
Arachidonic acid metabolism | |||||
Linoleic acid metabolism | |||||
alpha-Linolenic acid metabolism | |||||
Ras signaling pathway | |||||
Vascular smooth muscle contraction | |||||
Pancreatic secretion | |||||
Fat digestion and absorptionhsa00500:Starch and sucrose metabolism | |||||
Insulin signaling pathway | |||||
Glucagon signaling pathwayhsa04520:Adherens junction | |||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cellsinsulin_pathway:Insulin Pathway | ||||
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||||
Signaling events mediated by PTP1B | |||||
Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
Signaling events mediated by TCPTP | |||||
IGF1 pathway | |||||
EGF receptor (ErbB1) signaling pathway | |||||
Posttranslational regulation of adherens junction stability and dissassembly | |||||
PDGFR-beta signaling pathway | |||||
N-cadherin signaling events | |||||
PathWhiz Pathway | Steroidogenesis | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | ||||
Metabolism of steroid hormones and vitamin D | |||||
Glucocorticoid & Mineralcorticoid MetabolismWP2740:Glycerophospholipid biosynthesisWP500:Glycogen Metabolism | |||||
Metabolism of carbohydratesWP481:Insulin Signaling | |||||
Growth hormone receptor signaling | |||||
Leptin signaling pathway | |||||
Interferon gamma signaling | |||||
Interferon alpha/beta signaling | |||||
Integrin alphaIIb beta3 signaling | |||||
References | |||||
Ref 525684 | J Nat Prod. 1999 Dec;62(12):1624-6.DNA polymerase beta inhibitors from Baeckea gunniana. | ||||
Ref 527616 | Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. | ||||
Ref 530285 | J Nat Prod. 2009 Aug;72(8):1414-8.Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 530656 | Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. Epub 2010 Jan 11.11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. |
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