Drug Information

Drug General Information
Drug ID
D07OBG
Former ID
DNC007985
Drug Name
5-chloro-2-(4-phenylbutyl)isoindoline-1,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528834]
Structure
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2D MOL

3D MOL
Formula
C18H16ClNO2
Canonical SMILES
C1=CC=C(C=C1)CCCCN2C(=O)C3=C(C2=O)C=C(C=C3)Cl
InChI
1S/C18H16ClNO2/c19-14-9-10-15-16(12-14)18(22)20(17(15)21)11-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9-10,12H,4-5,8,11H2
InChIKey
QQYWRVQHDFXEFG-UHFFFAOYSA-N
PubChem Compound ID
44440475
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [528834]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 528834Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. Epub 2007 Apr 30.Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
Ref 528834Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. Epub 2007 Apr 30.Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.

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