Drug Information

Drug General Information
Drug ID
D07QMR
Former ID
DNC013293
Drug Name
N-(1-(4-phenylbutyl)piperidin-4-yl)-1-naphthamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528639]
Structure
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2D MOL

3D MOL
Formula
C26H30N2O
Canonical SMILES
C1CN(CCC1NC(=O)C2=CC=CC3=CC=CC=C32)CCCCC4=CC=CC=C4
InChI
1S/C26H30N2O/c29-26(25-15-8-13-22-12-4-5-14-24(22)25)27-23-16-19-28(20-17-23)18-7-6-11-21-9-2-1-3-10-21/h1-5,8-10,12-15,23H,6-7,11,16-20H2,(H,27,29)
InChIKey
JATDEOORDLHCRO-UHFFFAOYSA-N
PubChem Compound ID
44426502
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [528639]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528639Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.
Ref 528639Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.

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