Drug Information

Drug General Information
Drug ID
D07UHX
Former ID
DIB005256
Drug Name
9-AMINOCAMPTOTHECIN
Synonyms
IDEC-132; (S)-10-Amino-4-ethyl-4-hydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; 9-Amino-20(S)-camptothecin
Drug Type
Small molecular drug
Indication Acquired immune deficiency syndrome [ICD9: 42; ICD10:B20] Phase 2 [521423]
Structure
Download
2D MOL

3D MOL
Formula
C20H17N3O4
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC=C(C5=C4)N)<br />O
InChI
1S/C20H17N3O4/c1-2-20(26)13-7-16-17-10(6-11-14(21)4-3-5-15(11)22-17)8-23(16)18(24)12(13)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1
InChIKey
FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS Number
CAS 91421-43-1
PubChem Compound ID
72402
PubChem Substance ID
483848, 600881, 8195177, 11408968, 12014702, 14876953, 14876954, 26725257, 43128571, 50028358, 57318699, 77695393, 87560557, 96023346, 99373552, 99432308, 103073229, 103082936, 103170467, 103910998, 103922005, 104352855, 117586313, 119525751, 124796287, 124953919, 127347071, 127903358, 135030378, 137138142, 142371086, 152036014, 152227690, 160809182, 162179182, 162937855, 163374696, 164758081, 170559265, 172860100, 174531450, 178115205, 179151428, 184538696, 188900245, 198973567, 223445740, 223603491, 225031198, 226414396
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [525970]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 521423ClinicalTrials.gov (NCT00001427) A Phase II Trial of 72-Hour Continuous IV Infusion of 9-Aminocamptothecin With G-CSF Support in Patients With Advanced Ovarian Cancer Previously Treated With Paclitaxel and Cisplatin. U.S. National Institutes of Health.
Ref 525970Intraperitoneal topoisomerase-I inhibitors. Preliminary findings with 9-aminocamptothecin. Ann N Y Acad Sci. 2000;922:178-87.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.