Drug General Information
Drug ID	D08HIH
Former ID	DIB001036
Drug Name	ERB-196
Synonyms	WAY-196; WAY-202196; Estrogen receptor beta agonist (oral, inflammation/sepsis), Wyeth
Indication	Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]		Discontinued in Phase 1	[548018]
Company	Wyeth
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c2c(cc(c3cc(c(cc3)O)F)c1)ccc(c2)O)C#N
CAS Number	CAS 550997-55-2
Target and Pathway
Target(s)	Estrogen receptor beta	Target Info	Agonist	[528229]
KEGG Pathway	Estrogen signaling pathway
	Prolactin signaling pathway
Pathway Interaction Database	Plasma membrane estrogen receptor signaling
	Validated nuclear estrogen receptor beta network
	Validated nuclear estrogen receptor alpha network
Reactome	Nuclear Receptor transcription pathway
WikiPathways	SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Integrated Pancreatic Cancer Pathway
	Nuclear Receptors
References
Ref 548018	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021229)
Ref 528229	WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Crit Care Med. 2006 Aug;34(8):2188-93.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.