Drug Information

Drug General Information
Drug ID
D08TIQ
Former ID
DNCL001918
Drug Name
Iobenguane I 123 injection
Synonyms
AdreView (TN)
Drug Type
Small molecular drug
Indication Heart failure diagnosis [ICD9: 428; ICD10:I50] Approved [524423], [551871]
Company
GE Healthcare
Formula
C8H10IN3
Canonical SMILES
C1=CC(=CC(=C1)I)CN=C(N)N
InChI
1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
InChIKey
PDWUPXJEEYOOTR-UHFFFAOYSA-N
CAS Number
CAS 139755-80-9
PubChem Compound ID
60860
PubChem Substance ID
7398973, 11111341, 11111342, 11466518, 11467638, 11486016, 14750688, 24278499, 43118198, 47349354, 47573370, 47646555, 47720604, 48169363, 49698519, 50111105, 56219166, 57314158, 77939172, 85788868, 90341658, 99222771, 103113617, 103113618, 103215608, 104321834, 117356661, 117356662, 124749883, 124880479, 125820672, 127320057, 127320058, 127320059, 127320060, 127320061, 127320062, 127320063, 127320064, 127320065, 127320066, 128901924, 135114605, 137102707, 137138944, 142124139, 162916309, 175427085, 179225831, 179235742
SuperDrug ATC ID
V09IX01
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [529941]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 524423ClinicalTrials.gov (NCT01936649) Open-label, Test-retest Study Assessing Reproducibility of Quantitative Measurements of Myocardial Uptake of AdreView.. U.S. National Institutes of Health.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.

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