Drug General Information
Drug ID
D08VMW
Former ID
DIB015816
Drug Name
MP-529
Synonyms
SGI-1097; SGI-1215; SGI-498; SGI-503; Oral aurora kinase inhibitor (cancer), Montigen
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543524]
Company
Montigen Pharmaceuticals Inc
Structure
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2D MOL

3D MOL

Canonical SMILES
O=S(=O)(c1ccc(NC(=S)N2CCN(c3ncnc4c3c3c(cc(c(c3)OC)OC)[n<br />H]4)CC2)cc1)Nc1ccc(cc1)F
Target and Pathway
Target(s) Aurora protein kinase Target Info Inhibitor [543524]
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 543524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).
Ref 543524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).

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