Drug General Information
Drug ID
D09BTK
Former ID
DIB012794
Drug Name
NCX-1000
Synonyms
Nitric oxide ursodiol derivative, NicOx/Axcan; UDCA derivative, NicOx/Axcan; Ursodeoxycholic acid derivative, NicOx/Axcan
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Phase 2 [521941]
Company
NicOx SA
Structure
Download
2D MOL

3D MOL

Formula
C38H55NO10
Canonical SMILES
[C@@]12([C@H]([C@H]3C([C@@]4([C@H](C[C@@H]3O)C[C@@H](CC<br />4)O)C)CC2)CC[C@@H]1[C@@H](CCC(=O)Oc1c(cc(/C=C/C(=O)OCCC<br />CO[N+](=O)[O-])cc1)OC)C)C
CAS Number
CAS 401519-96-8
PubChem Compound ID
Target and Pathway
Target(s) Caspase Target Info Modulator [527200]
References
Ref 521941ClinicalTrials.gov (NCT00414869) Preliminary Efficacy and Tolerability of NCX-1000 After Repeated Oral Doses in Patients With Elevated Portal Pressure. U.S. National Institutes of Health.
Ref 527200Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol. 2004 Sep;143(1):33-42.

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