Drug Information

Drug General Information
Drug ID
D09IOI
Former ID
DAP001149
Drug Name
Amoxapine
Synonyms
Amoxan; Amoxapina; Amoxapinum; Amoxepine; Ascendin; Asendin; Asendis; Defanyl; Demolox; Desmethylloxapin; Desmethylloxapine; Moxadil; CL 67772; A-129; Amoxapina [INN-Spanish]; Amoxapinum [INN-Latin]; Asendin (TN); Asendis (TN); CL-67772; Defanyl (TN); Demolox (TN); KS-1197; Moxadil (TN); CL-67,772; Amoxapine (JP15/USP/INN); Amoxapine [USAN:BAN:INN:JAN]; 2-Chlor-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepin; 2-Chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]oxazepine; 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine; 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine; 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine; 2-chloro-11-piperazin-1-yldibenzo[b,f][1,4]oxazepine; 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Approved [538247], [539292], [551871]
Therapeutic Class
Antidepressants
Structure
Download
2D MOL

3D MOL
Formula
C17H16ClN3O
InChI
InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChIKey
QWGDMFLQWFTERH-UHFFFAOYSA-N
CAS Number
CAS 14028-44-5
PubChem Compound ID
2170
PubChem Substance ID
855963, 4621375, 7847295, 7978696, 8150155, 8151476, 10321488, 10507662, 11110675, 11110676, 11335411, 11360650, 11363340, 11365902, 11368464, 11371973, 11374794, 11376626, 11461622, 11466130, 11467250, 11484886, 11485759, 11489061, 11490882, 11493032, 11494260, 12013426, 14950373, 17404679, 24278075, 26613170, 26680165, 26747067, 26751577, 29221349, 46509117, 47291025, 47662153, 47662154, 47662155, 47736356, 48110341, 48110342, 48110343, 48259108, 48334368, 48415558, 49698344, 49846684
SuperDrug ATC ID
N06AA17
SuperDrug CAS ID
cas=014028445
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [537875]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 538247FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 072688.
Ref 539292(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 201).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537875Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug;33(8):1017-25.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.