Drug General Information
Drug ID	D09RNK
Former ID	DNC013908
Drug Name	5-Biphenyl-4-ylethynyl-pyrimidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529531]
Structure		Download 2D MOL 3D MOL
Formula	C18H12N2
Canonical SMILES	C1=CC=C(C=C1)C2=CC=C(C=C2)C#CC3=CN=CN=C3
InChI	1S/C18H12N2/c1-2-4-17(5-3-1)18-10-8-15(9-11-18)6-7-16-12-19-14-20-13-16/h1-5,8-14H
InChIKey	WSPLFBLWQURLSJ-UHFFFAOYSA-N
PubChem Compound ID	44560632
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[529531]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529531	Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. Epub 2008 May 29.Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.
Ref 529531	Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. Epub 2008 May 29.Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.

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