Drug Information

Drug General Information
Drug ID
D09ZOA
Former ID
DNC009764
Drug Name
2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530746]
Structure
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2D MOL

3D MOL
Formula
C14H14N2O4S
Canonical SMILES
C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)NCC(=O)NO
InChI
1S/C14H14N2O4S/c17-14(16-18)10-15-21(19,20)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,15,18H,10H2,(H,16,17)
InChIKey
NKGRTRASISLCCZ-UHFFFAOYSA-N
PubChem Compound ID
25049753
Target and Pathway
Target(s) Matrix metalloproteinase-14 Target Info Inhibitor [530746]
ADAM 17 Target Info Inhibitor [530746]
KEGG Pathway TNF signaling pathway
GnRH signaling pathwayhsa04330:Notch signaling pathway
Alzheimer's disease
Epithelial cell signaling in Helicobacter pylori infection
PANTHER Pathway Alzheimer disease-presenilin pathwayP00003:Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Notch signaling pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
Signaling events mediated by focal adhesion kinaseerbb4_pathway:ErbB4 signaling events
TNF receptor signaling pathway
p75(NTR)-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix MetalloproteinasesR-HSA-1251985:Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7
M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
TNF signaling
Growth hormone receptor signaling
WikiPathways Senescence and Autophagy in Cancer
Activation of Matrix Metalloproteinases
Degradation of collagen
AGE/RAGE pathway
Matrix MetalloproteinasesWP61:Notch Signaling Pathway
Copper homeostasis
Notch Signaling Pathway
Growth hormone receptor signaling
BDNF signaling pathway
Alzheimers Disease
Signalling by NGF
Extrinsic Pathway for Apoptosis
References
Ref 530746J Med Chem. 2010 Mar 25;53(6):2622-35.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Ref 530746J Med Chem. 2010 Mar 25;53(6):2622-35.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

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