Drug Information

Drug General Information
Drug ID
D0A3HF
Former ID
DIB009758
Drug Name
VE-16084
Synonyms
ICE inhibitors, Sanofi Winthrop; VE-16084; WIN-67694
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Terminated [534169]
Company
Sterling Winthrop Products Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
C(=O)(N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC(=O)c1c(Cl)cc<br />cc1Cl)C)[C@@H](NC(=O)OCc1ccccc1)C(C)C
CAS Number
CAS 151594-01-3
Target and Pathway
Target(s) Interleukin-1 beta convertase Target Info Inhibitor [534169]
KEGG Pathway NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Amyotrophic lateral sclerosis (ALS)
Salmonella infection
Pertussis
Legionellosis
Influenza A
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database IL1-mediated signaling events
Direct p53 effectors
IFN-gamma pathway
Cellular roles of Anthrax toxin
Reactome NOD1/2 Signaling Pathway
Interleukin-1 processing
The NLRP3 inflammasome
WikiPathways MAPK Signaling Pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Apoptosis
Amyotrophic lateral sclerosis (ALS)
Parkin-Ubiquitin Proteasomal System pathway
Interleukin-1 processing
Apoptosis Modulation and Signaling
NOD pathway
References
Ref 534169Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine. 1996 May;8(5):377-86.
Ref 534169Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine. 1996 May;8(5):377-86.

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