Drug General Information
Drug ID
D0A5MR
Former ID
DNC008666
Drug Name
MK-0354
Drug Type
Small molecular drug
Indication Discovery agent Phase 2 [521843], [541103]
Structure
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2D MOL

3D MOL

Formula
C7H8N6
InChI
InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2,(H,8,9)(H,10,11,12,13)
InChIKey
LTQYSJKGRPGMPO-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Nicotinic acid receptor Target Info Inhibitor [531020]
References
Ref 521843ClinicalTrials.gov (NCT00337415) MK0354 Clinical Efficacy and Tolerability Study (0354-004). U.S. National Institutes of Health.
Ref 541103(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5784).
Ref 531020Bioorg Med Chem Lett. 2010 Aug 1;20(15):4472-4. Epub 2010 Jun 10.GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.

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