Drug Information

Drug General Information
Drug ID
D0A9YA
Former ID
DAP000044
Drug Name
Dutasteride
Synonyms
Avodart; Avolve; Duagen; Dutasteride [USAN]; GG 745; GI 198745; Avidart (TN); Avodart (TN); Avodart, Dutasteride; Avolve (TN); Duagen (TN); Duprost (TN); Dutagen (TN); Dutas (TN); GG-745; GI-198745; GI-198745X; Dutasteride (JAN/USAN/INN); N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide; Alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide; (1S,3aS,3bS,5aR,9aR,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; (5-alpha,17-beta)-N-{2,5 bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide;dutasteride; (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Drug Type
Small molecular drug
Indication Benign prostatic hyperplasia [ICD9: 600; ICD10:N40] Approved [536709], [542481]
Prostate cancer [ICD9: 185; ICD10:C61] Phase 3 [536709], [542481]
Therapeutic Class
Anticancer Agents
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C27H30F6N2O2
InChI
InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
InChIKey
JWJOTENAMICLJG-QWBYCMEYSA-N
CAS Number
CAS 164656-23-9
PubChem Compound ID
6918296
PubChem Substance ID
12014955, 14836607, 14909902, 17194796, 17397907, 43529678, 46504830, 53787436, 57371871, 71824992, 79317270, 81092907, 85709776, 91145910, 91612910, 99437024, 103770952, 104179082, 114787740, 118046363, 124757077, 125163881, 125311722, 126596711, 131343417, 135109202, 135684130, 136183917, 136367959, 136375517, 136980377, 137005555, 137181708, 142643797, 144115926, 144205752, 152059555, 152063850, 162036214, 162175331, 163797282, 165698504, 172093501, 174477509, 174527666, 175265390, 176484953, 179150039, 187051760, 210274902
SuperDrug ATC ID
G04CB02
SuperDrug CAS ID
cas=164656239
Target and Pathway
Target(s) 5-alpha reductase Target Info Inhibitor [537501]
References
Ref 5367095alpha-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction. Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):389-402.
Ref 542481(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7457).
Ref 537501The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme? Can Urol Assoc J. 2009 Jun;3(3 Suppl 2):S109-14.

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