Drug Information

Drug General Information
Drug ID
D0B6PX
Former ID
DNC003631
Drug Name
N,N-Dimethylaminoethyl 18-methoxycoronaridinate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526639]
Structure
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2D MOL

3D MOL
Formula
C25H35N3O3
Canonical SMILES
CN(C)CCOC(=O)C12CC3CC(C1N(C3)CCC4=C2NC5=CC=CC=C45)CCOC
InChI
1S/C25H35N3O3/c1-27(2)11-13-31-24(29)25-15-17-14-18(9-12-30-3)23(25)28(16-17)10-8-20-19-6-4-5-7-21(19)26-22(20)25/h4-7,17-18,23,26H,8-16H2,1-3H3/t17?,18-,23-,25+/m0/s1
InChIKey
NLVQALDWFSJMGA-BJASRFDRSA-N
PubChem Compound ID
46877887
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, beta-4 chain Target Info Inhibitor [526639]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Chromaffin Cells
References
Ref 526639J Med Chem. 2003 Jun 19;46(13):2716-30.Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents.
Ref 526639J Med Chem. 2003 Jun 19;46(13):2716-30.Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents.

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