Drug Information

Drug General Information
Drug ID
D0BA9U
Former ID
DAP001207
Drug Name
Levonorgestrel
Synonyms
Capronor; DNorgestrel; Follistrel; Jadelle; Levlen; Levonelle; Levonorgestrelum; Levonova; Methylnorethindrone; Microgyn; Microlut; Microlution; Microluton; Microval; Mirena; Monovar; NORPLANT; Neogest; NorLevo; Nordet; Norgeston; Norgestrel; Norgestrelum; Ovranette; Ovrette; Postinor; Preven; Tetragynon; Triagynon; Triciclor; Trigoa; Trivora; LD norgestrel [French]; Ld norgestrel; Levlen ED; Levonorgestrel implants; Logynon ED; Microgest ED; Microgynon CD; Norgestrel [Progestins]; Norplant II; Norplant System in Plastic Container; Plan B; Triquilar ED; Microgynon 21; Microgynon 28; Microgynon 30 ED; Minivlar 30; Monofeme 28; Neogynon 21; Nordette 21; Nordette 28; Norplant 2; SH 70850; SH 850; Stediril 30; Trifeme 28; Trinordiol 21; Trinordiol 28; Triphasil 21; Triphasil 28; Wy 3707; Alpha-Norgestrel; Component of Lo/ovral; D-Norgestrel; Dl-Norgestrel; FH 122-A; LO/Ovral; Levonorgestrelum [INN-Latin]; Levora-21; Levora-28; Mirena (TN); Norgestrelum [INN-Latin]; Norplant (TN); Norplant-2; Ovoplex 30-150; Ovral-Lo; Ovrette (TN); Postinor-2; Rigevidon 21+7; SOH-075; Tri-Levlen 21; Wy-3707; Wy-5104; E-Gen-C; Levonorgestrel [USAN:INN:BAN]; D(-)-Norgestrel; Levonorgestrel (JAN/USP/INN); Norgestrel (JP15/USP/INN); Norgestrel [USAN:BAN:INN:JAN]; Norgestrel [USAN:INN:BAN:JAN]; D-(-)-Norgestrel; Levonelle, D-Norgestrel, Levonova, Levonorgestrel; Norgestrel-(-)-D; Dl-13-beta-Ethyl-17-alpha-ethynyl-19-nortestosterone; (-)-Norgestrel; 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE; 13-Ehyl-17alpha-ethynyl-17-hydroxygon-4-en-3-one; 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one; 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one; 13-Ethyl-17alpha-ethynylgon-4-en-17beta-ol-3-one; 13-beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one; 13beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one; 17-Ethynyl-18-methyl-19-nortestosterone; 17-alpha-Ethynyl-13-ethyl-19-nortestosterone; 17alpha-Ethynyl-13-ethyl-19-nortestosterone; 17alpha-Ethynyl-13beta-ethyl-3-oxo-4-estren-17beta-ol; 17alpha-Ethynyl-17-hydroxy-18-methylestr-4-en-3-one; 17alpha-Ethynyl-18-homo-19-nor-testosterone; 17alpha-Ethynyl-18-homo-19-nortestosterone; 17alpha-ethynyl-17beta-hydroxy-18a-homoestr-4-en-3-one; 18,19-Dinor-4-pregnen-20-yn-3-one; 18-Methyl-17-alpha-ethynyl-19-nortestosterone; 18-Methylnorethisterone; 72-HOURS
Drug Type
Small molecular drug
Indication Hormonal contraceptives [ICD10:Z30] Approved [536361], [539908]
Therapeutic Class
Contraceptive Agents
Structure
Download
2D MOL

3D MOL
Formula
C21H28O2
InChI
InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
InChIKey
WWYNJERNGUHSAO-XUDSTZEESA-N
CAS Number
CAS 17489-40-6
PubChem Compound ID
13109
PubChem Substance ID
10349, 10353, 7848013, 7848017, 7889451, 8159864, 10321210, 11466801, 11467921, 11486521, 11532896, 14801049, 14923455, 24702331, 24897561, 26719646, 29215264, 29281281, 46386677, 46508082, 46509177, 47275737, 47499732, 48094724, 48318626, 49698635, 49963134, 49963135, 50109848, 53787534, 53789027, 56352919, 56422866, 57654445, 71821473, 76968564, 81093159, 85787473, 91147155, 92125812, 92308478, 92309282, 93167212, 103469384, 103913690, 104253340, 104330879, 117622363, 121363483, 124658858
ChEBI ID
ChEBI:6443
SuperDrug ATC ID
G03AC03; G03AD01
SuperDrug CAS ID
cas=000797637
Target and Pathway
Target(s) Progesterone receptor Target Info Binder [537153]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 539908(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2881).
Ref 537153Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins. Mol Pharmacol. 2009 Jun;75(6):1317-24. Epub 2009 Mar 16.

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