Drug Information

Drug General Information
Drug ID
D0BK8V
Former ID
DIB018525
Drug Name
2',3'-ddATP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539061]
Structure
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2D MOL

3D MOL
Formula
C10H16N5O11P3
InChI
InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1
InChIKey
OAKPWEUQDVLTCN-NKWVEPMBSA-N
PubChem Compound ID
65304
PubChem Substance ID
598949, 824264, 7886885, 8189618, 15332184, 26711134, 26711140, 26711143, 26713503, 43122122, 46506011, 57315424, 75089223, 85285746, 85285750, 92728881, 92728886, 96021776, 96021782, 103059116, 103465077, 104050360, 104333421, 124360959, 124360962, 125317023, 125317026, 128780718, 134350093, 135021827, 135651389, 144220391, 144223538, 152138017, 160965400, 164794748, 198988734, 226458903, 249565447, 249565448, 252329443
Target and Pathway
Target(s) P2Y purinoceptor 1 Target Info Agonist [534388]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539061(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1709).
Ref 534388An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44.

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