Drug Information

Drug General Information
Drug ID
D0BM7O
Former ID
DIB019789
Drug Name
Duo3
Synonyms
DUO3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542618]
Structure
Download
2D MOL

3D MOL
Formula
C29H26Cl4N4O2+2
InChI
InChI=1S/C29H26Cl4N4O2/c30-26-4-1-5-27(31)24(26)20-38-34-18-22-8-14-36(15-9-22)12-3-13-37-16-10-23(11-17-37)19-35-39-21-25-28(32)6-2-7-29(25)33/h1-2,4-11,14-19H,3,12-13,20-21H2/q+2/b34-18+,35-19+
InChIKey
RAHLDBGBLYIYDN-WKCPDWHCSA-N
PubChem Compound ID
10101670
PubChem Substance ID
15409509, 24443088, 39740752, 80742915, 103206744, 103973267, 104162282
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [527734]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 542618(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7635).
Ref 527734Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors. Mol Pharmacol. 2005 Dec;68(6):1597-610. Epub 2005 Sep 12.

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