Drug Information

Drug General Information
Drug ID
D0C2DM
Former ID
DIB020286
Drug Name
LY593093
Synonyms
LY-593093; LY 593093
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540843]
Structure
Download
2D MOL
Formula
C32H30FN3O2
InChI
InChI=1S/C32H30FN3O2/c1-21(36(2)20-22-8-15-27(33)16-9-22)34-28-17-14-26-18-30(37)31(29(26)19-28)35-32(38)25-12-10-24(11-13-25)23-6-4-3-5-7-23/h3-17,19,30-31,37H,18,20H2,1-2H3,(H,35,38)/t30-,31-/m1/s1
InChIKey
KOQVBYSCBCRVQJ-FIRIVFDPSA-N
PubChem Compound ID
9893054
PubChem Substance ID
14933586, 15157547, 24178118, 45639988, 80173762, 85180262, 139486908, 178102092, 231177202, 239252084, 242916000
Target and Pathway
Target(s) Muscarinic receptor Target Info Agonist [531470]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540843(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5441).
Ref 531470Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist. J Pharmacol Exp Ther. 2011 Aug;338(2):622-32.

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