Drug General Information
Drug ID
D0C8KF
Former ID
DCL000215
Drug Name
Resiquimod
Synonyms
Resiquimod [INN]; R 848; S 28463; R-848; S-28463; VML-600; 1-(4-Amino-2-ethoxymethyl-imidazo[4,5-c]quinolin-1-yl)-2-methyl-propan-2-ol; 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 4-amino-2-(ethoxymethyl)-a,a-dimethyl-1h-imidazo[4,5-c]quinoline-1-ethanol; 4-amino-2-ethoxymethyl-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol
Drug Type
Small molecular drug
Indication Herpes simplex virus infection [ICD9: 54; ICD10:B00] Phase 1/2 [468141], [546884]
Company
3M Pharma.
Structure
Download
2D MOL

3D MOL

Formula
C17H22N4O2
InChI
InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
InChIKey
BXNMTOQRYBFHNZ-UHFFFAOYSA-N
CAS Number
CAS 144875-48-9
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:36706
Target and Pathway
Target(s) Toll-like receptor 7 Target Info Modulator
Toll-like receptor 8 Target Info Modulator
KEGG Pathway Toll-like receptor signaling pathway
Measles
Influenza Ahsa04620:Toll-like receptor signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_22:Leptin Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosomeR-HSA-1679131:Trafficking and processing of endosomal TLR
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway
References
Ref 468141(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5051).
Ref 546884Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010858)

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