Drug Information

Drug General Information
Drug ID
D0CO3N
Former ID
DIB018021
Drug Name
esuberaprost
Synonyms
APS-314D free acid; BPS-314d
Drug Type
Small molecular drug
Indication Gout [ICD9: 274.00274.1274.8274.9; ICD10:M10] Phase 3 [533330]
Structure
Download
2D MOL
Formula
C24H30O5
InChI
InChI=1S/C24H30O5/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28)/b13-12+/t15-,17-,19+,20+,21-,23-/m0/s1
InChIKey
CTPOHARTNNSRSR-NOQAJONNSA-N
PubChem Compound ID
10501053
PubChem Substance ID
15526048, 22824207, 41881685, 51036910, 163641078, 194189081, 198976286, 198978286, 238174020, 252166526
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [533330]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 533330Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets. Arzneimittelforschung. 1989 Apr;39(4):495-9.
Ref 533330Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets. Arzneimittelforschung. 1989 Apr;39(4):495-9.

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