Drug General Information
Drug ID	D0DX4J
Former ID	DCL001073
Drug Name	P1446A-05
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 1	[531342]
Company	Nicholas Piramal
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Cell division protein kinase 4	Target Info	Inhibitor	[537564]
KEGG Pathway	Cell cycle
	p53 signaling pathway
	PI3K-Akt signaling pathway
	Tight junction
	T cell receptor signaling pathway
	Hepatitis B
	Measles
	HTLV-I infection
	Pathways in cancer
	Viral carcinogenesis
	Pancreatic cancer
	Glioma
	Melanoma
	Bladder cancer
	Chronic myeloid leukemia
	Small cell lung cancer
	Non-small cell lung cancer
NetPath Pathway	TCR Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Validated targets of C-MYC transcriptional activation
	ATF-2 transcription factor network
	FOXM1 transcription factor network
	Regulation of retinoblastoma protein
Reactome	Oxidative Stress Induced Senescence
	Senescence-Associated Secretory Phenotype (SASP)
	Oncogene Induced Senescence
	RMTs methylate histone arginines
	Transcriptional regulation of white adipocyte differentiation
	Ubiquitin-dependent degradation of Cyclin D1
	Cyclin D associated events in G1
	Meiotic recombination
WikiPathways	DNA Damage Response
	G1 to S cell cycle control
	Ovarian Infertility Genes
	PPAR Alpha Pathway
	Bladder Cancer
	S Phase
	Transcriptional Regulation of White Adipocyte Differentiation
	Meiotic Recombination
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Mitotic G1-G1/S phases
	Cell Cycle
	miRNA Regulation of DNA Damage Response
References
Ref 531342	Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154.
Ref 537564	Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.

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