Drug General Information
Drug ID	D0E3KD
Former ID	DNC002875
Drug Name	9-(4-Hydroxyphenyl)-2,7-Phenanthroline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551393]
Structure		Download 2D MOL 3D MOL
Formula	C18H12N2O
Canonical SMILES	C1=CC(=O)C=CC1=C2C=C3C(=CC=C4C3=CNC=C4)N=C2
InChI	1S/C18H12N2O/c21-15-4-1-12(2-5-15)14-9-16-17-11-19-8-7-13(17)3-6-18(16)20-10-14/h1-11,19H
InChIKey	LQCQDYRLKBYBNB-UHFFFAOYSA-N
PubChem Compound ID	5326727
PubChem Substance ID	829652, 7885567, 34951423, 39299528, 46392886, 46507868, 46516286, 53696368, 103554408, 113905037, 137184963, 160966723, 180398207, 230251233, 245720424
Target and Pathway
Target(s)	Mitogen-activated protein kinase 10	Target Info	Inhibitor	[551393]
KEGG Pathway	MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	cAMP signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	Protein processing in endoplasmic reticulum
	Wnt signaling pathway
	Osteoclast differentiation
	Focal adhesion
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Fc epsilon RI signaling pathway
	TNF signaling pathway
	Neurotrophin signaling pathway
	Retrograde endocannabinoid signaling
	Dopaminergic synapse
	Inflammatory mediator regulation of TRP channels
	Insulin signaling pathway
	GnRH signaling pathway
	Progesterone-mediated oocyte maturation
	Prolactin signaling pathway
	Adipocytokine signaling pathway
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Epithelial cell signaling in Helicobacter pylori infection
	Shigellosis
	Salmonella infection
	Pertussis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Tuberculosis
	Hepatitis C
	Hepatitis B
	Influenza A
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Colorectal cancer
	Pancreatic cancer
	Choline metabolism in cancer
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Apoptosis signaling pathway
	B cell activation
	EGF receptor signaling pathway
	FAS signaling pathway
	FGF signaling pathway
	Integrin signalling pathway
	Interferon-gamma signaling pathway
	Parkinson disease
	TGF-beta signaling pathway
	Ras Pathway
	CCKR signaling map ST
Pathway Interaction Database	Noncanonical Wnt signaling pathway
	CD40/CD40L signaling
	FAS (CD95) signaling pathway
	Glucocorticoid receptor regulatory network
	FoxO family signaling
	p75(NTR)-mediated signaling
	ErbB2/ErbB3 signaling events
	PDGFR-beta signaling pathway
	Nephrin/Neph1 signaling in the kidney podocyte
Reactome	Oxidative Stress Induced Senescence
	FCERI mediated MAPK activation
	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
	Activation of the AP-1 family of transcription factors
WikiPathways	Toll-like receptor signaling pathway
	DNA Damage Response (only ATM dependent)
	G13 Signaling Pathway
	Insulin Signaling
	Wnt Signaling Pathway
	MAPK Cascade
	Oxidative Stress
	Wnt Signaling Pathway and Pluripotency
	Apoptosis Modulation by HSP70
	MAPK Signaling Pathway
	Nanoparticle-mediated activation of receptor signaling
	Structural Pathway of Interleukin 1 (IL-1)
	Apoptosis
	BDNF signaling pathway
	Integrin-mediated Cell Adhesion
	Regulation of toll-like receptor signaling pathway
References
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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