Drug Information

Drug General Information
Drug ID
D0E4FG
Former ID
DIB002988
Drug Name
MOZENAVIR MESILATE
Synonyms
DMP-450; Mozenavir mesilate < Prop INNM >; XM-412 (free base); (4R,5S,6S,7R)-1,3-Bis(3-aminobenzyl)-4,7-dibenzyl-5,6-dihydroxyhexahydro-1,3-diazepin-2-one dimethanesulfonate
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 2 [545709]
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Canonical SMILES
Nc1cccc(CN2[C@H](Cc3ccccc3)[C@H](O)[C@@H](O)[C@@H](Cc4c<br />cccc4)N(Cc5cccc(N)c5)C2=O)c1
InChI
1S/C33H36N4O3/c34-27-15-7-13-25(17-27)21-36-29(19-23-9-3-1-4-10-23)31(38)32(39)30(20-24-11-5-2-6-12-24)37(33(36)40)22-26-14-8-16-28(35)18-26/h1-18,29-32,38-39H,19-22,34-35H2/t29-,30-,31+,32+/m1/s1
InChIKey
KYRSNWPSSXSNEP-ZRTHHSRSSA-N
CAS Number
CAS 153182-59-3
Target and Pathway
Target(s) HIV protease Target Info Inhibitor [534206]
References
Ref 545709Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004305)
Ref 534206Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450. Chem Biol. 1996 Apr;3(4):301-14.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.