Drug Information

Drug General Information
Drug ID
D0EM4S
Former ID
DNCL001608
Drug Name
JNJ-39439335
Drug Type
Small molecular drug
Indication Musculoskeletal pain [ICD9: 338,780; ICD10:R52, G89] Phase 1 [523962]
Company
Johnson & Johnson Pharmaceutical Research & Development
Structure
Download
2D MOL

3D MOL
Formula
C25H21F3N2O
Canonical SMILES
CC(C)(C1=CC=CC=C1C2=CC3=C(C=C2)N=C(N3)C=CC4=CC=C(C=C4)C<br />(F)(F)F)O
InChI
1S/C25H21F3N2O/c1-24(2,31)20-6-4-3-5-19(20)17-10-13-21-22(15-17)30-23(29-21)14-9-16-7-11-18(12-8-16)25(26,27)28/h3-15,31H,1-2H3,(H,29,30)/b14-9+
InChIKey
ORDHXXHTBUZRCN-NTEUORMPSA-N
PubChem Compound ID
17751090
PubChem Substance ID
29204727, 139961280, 162108927, 164144444, 172232463, 198952488, 227972834, 227973621
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Antagonist [533205]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 523962ClinicalTrials.gov (NCT01631487) A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JNJ-39439335 in Healthy Japanese and Caucasian Adult Male Participants. U.S. National Institutes of Health.
Ref 533205Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). J Med Chem. 2015 May 14;58(9):3859-74.

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