Drug General Information
Drug ID	D0EN4G
Former ID	DIB002680
Drug Name	R-102444
Synonyms	Dopamine D2 antagonists, Sankyo; 5-HT2 antagonists, Sankyo
Indication	Pancreatitis [ICD9: 577.0-577.1; ICD10:K85, K86.0K86.1]		Terminated	[547365]
Company	Sankyo Co Ltd
Structure		Download 2D MOL
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Modulator	[535964]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 547365	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015510)
Ref 535964	Effects of R-102444, an orally active 5-HT2A receptor antagonist, in rat models of peripheral vascular disease. Vascul Pharmacol. 2004 Feb;41(1):7-13.

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