TTD | Drug: D0ES4S

Drug General Information
Drug ID	D0ES4S
Former ID	DNC011410
Drug Name	RP-68303
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[545423]
Structure		Download 2D MOL 3D MOL
Formula	C25H29FN4O2S
Canonical SMILES	C1CC2=C3C(=CC=C2)N(S(=O)(=O)N3C1)CCN4CCC(CC4)CC5=CNC6=C<br />5C=C(C=C6)F
InChI	1S/C25H29FN4O2S/c26-21-6-7-23-22(16-21)20(17-27-23)15-18-8-11-28(12-9-18)13-14-29-24-5-1-3-19-4-2-10-30(25(19)24)33(29,31)32/h1,3,5-7,16-18,27H,2,4,8-15H2
InChIKey	NZUSTSFFNOEAHE-UHFFFAOYSA-N
PubChem Compound ID	183775
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[534052]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 545423	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003204)
Ref 534052	J Med Chem. 1993 Apr 30;36(9):1194-202.New indole derivatives as potent and selective serotonin uptake inhibitors.

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Drug Information