Drug Information

Drug General Information
Drug ID
D0G3DB
Former ID
DIB018416
Drug Name
[3H]SR 121463A
Synonyms
[3H]-SR121463A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539413]
Structure
Download
2D MOL
Formula
C33H45N3O8S
InChI
InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)
InChIKey
QKXJWFOKVQWEDZ-UHFFFAOYSA-N
PubChem Compound ID
158348
PubChem Substance ID
7980652, 10253307, 14790069, 14936858, 14936859, 46233802, 80773073, 113439716, 124965786, 134340561, 134340562, 135113214, 135337868, 135651071, 135651208, 140278681, 198974765, 227839176, 229846171, 248102089, 248378196
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [534299]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539413(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2234).
Ref 534299Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist. J Clin Invest. 1996 Dec 15;98(12):2729-38.

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