Drug Information
Drug General Information | |||||
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Drug ID |
D0G5MT
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Former ID |
DIB018462
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Drug Name |
11-deoxy-PGE1
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Synonyms |
11-deoxy-PGE1; 11-deoxyprostaglandin E1; doproston
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539225] | ||
Structure |
Download2D MOL |
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Formula |
C20H34O4
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InChI |
InChI=1S/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
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InChIKey |
DPNOTBLPQOITGU-LDDQNKHRSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Prostaglandin E2 receptor EP3 subtype | Target Info | Agonist | [534595] | |
Prostaglandin E2 receptor, EP4 subtype | Target Info | Agonist | [525852] | ||
Prostaglandin E2receptor, EP2 subtype | Target Info | Agonist | [534478] | ||
KEGG Pathway | Calcium signaling pathway | ||||
cAMP signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Regulation of lipolysis in adipocytes | |||||
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction | |||||
Inflammatory mediator regulation of TRP channels | |||||
Renin secretion | |||||
Pathways in cancerhsa04024:cAMP signaling pathway | |||||
Pathways in cancer | |||||
References | |||||
Ref 525852 | Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. Br J Pharmacol. 2000 Aug;130(8):1919-26. | ||||
Ref 534478 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. | ||||
Ref 534595 | Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. |
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