Drug General Information
Drug ID
D0G9SH
Former ID
DIB012468
Drug Name
SA-5845
Synonyms
SA-5845; Carbon-11 labeled sigma opioid receptor ligands, Santen; FE-SA-4503; FE-SA-5845; Carbon-11-SA-4503; Carbon-11-SA-5845; 11C-SA-4503; 11C-SA-5845
Indication Central nervous system disease [ICD10:G00-G99] Phase 1 [526642], [527279], [532713]
Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Preclinical [525883]
Company
Santen Pharmaceutical Co Ltd
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Binder [526642], [527279], [532713]
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 525883Preclinical evaluation of [11C]SA4503: radiation dosimetry, in vivo selectivity and PET imaging of sigma1 receptors in the cat brain. Ann Nucl Med. 2000 Aug;14(4):285-92.
Ref 526642Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 527279Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.
Ref 532713Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 526642Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 527279Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.
Ref 532713Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.

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