Drug General Information
Drug ID
D0GJ7B
Former ID
DNC011100
Drug Name
NELOTANSERIN
Drug Type
Small molecular drug
Indication Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] Discontinued in Phase 2 [548083]
Structure
Download
2D MOL

3D MOL

Formula
C18H15BrF2N4O2
Canonical SMILES
CN1C(=C(C=N1)Br)C2=C(C=CC(=C2)NC(=O)NC3=C(C=C(C=C3)F)F)<br />OC
InChI
1S/C18H15BrF2N4O2/c1-25-17(13(19)9-22-25)12-8-11(4-6-16(12)27-2)23-18(26)24-15-5-3-10(20)7-14(15)21/h3-9H,1-2H3,(H2,23,24,26)
InChIKey
COSPVUFTLGQDQL-UHFFFAOYSA-N
CAS Number
CAS 839713-36-9
PubChem Compound ID
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548083Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021795)

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