Drug Information

Drug General Information
Drug ID
D0H8FH
Former ID
DAP000498
Drug Name
Indapamide
Synonyms
Arifon; Bajaten; Cormil; Damide; Fludex; Idapamide; Indaflex; Indamol; Indapamida; Indapamidum; Ipamix; Lozide; Lozol; Metindamide; Natrilix; Natrix; Noranat; Pressurai; Tandix; Tertensif; Veroxil; RHC 2555; SE 1520; USV 2555; Apo-Indapamide; Indapamida [INN-Spanish]; Indapamide (USP); Indapamidum [INN-Latin]; Lozol (TN); Natrilix (TN); Natrix (TN); Novo-Indapamide; Nu-Indapamide; S-1520; SE-1520; Indapamide (JAN/USP); Indapamide [USAN:INN:BAN:JAN]; N-[4-Chloro-3-sulfamoylbenzamido]-2-methylindoline; NLozol, Arifon, Fludex, Noranat, Veroxil, Tertensif, Indapamide; N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline; Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-(9CI); 1-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline; 3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide; 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide; 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [538270], [542217]
Therapeutic Class
Antihypertensive Agents
Company
Servier Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C16H16ClN3O3S
InChI
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
InChIKey
NDDAHWYSQHTHNT-UHFFFAOYSA-N
CAS Number
CAS 26807-65-8
PubChem Compound ID
3702
PubChem Substance ID
855885, 7548663, 7847411, 7979602, 8149386, 8152339, 11335683, 11360922, 11363811, 11366373, 11368935, 11371494, 11373532, 11377097, 11461894, 11484755, 11488796, 11490283, 11491832, 11494731, 14828553, 24895952, 26611782, 26680433, 26747199, 26747200, 29222825, 46508626, 47216741, 47515281, 48184956, 48259190, 48259191, 48334450, 49698709, 49832093, 49876093, 56413189, 56422467, 57321947, 57654295, 80156605, 80953761, 85086931, 85148358, 85788440, 87561081, 92124043, 92307457, 92309252
SuperDrug ATC ID
C03BA11
SuperDrug CAS ID
cas=026807658
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 1 Target Info Blocker [536209]
KEGG Pathway Adrenergic signaling in cardiomyocytes
Cholinergic synapse
Gastric acid secretion
Pancreatic secretion
Protein digestion and absorption
Vibrio cholerae infection
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Potassium Channels
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
TarBasePathway
References
Ref 538270FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074299.
Ref 542217(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7203).
Ref 536209Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. Eur J Pharmacol. 2006 Apr 24;536(1-2):78-84. Epub 2006 Mar 2.

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