Drug Information
Drug General Information | |||||
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Drug ID |
D0HS5V
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Former ID |
DNCL002613
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Drug Name |
Brivanib
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Drug Type |
Small molecular drug
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Company |
Bristol-Myers Squibb
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Structure |
Download2D MOL |
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Formula |
C19H19FN4O3
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InChI |
InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1
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InChIKey |
WCWUXEGQKLTGDX-LLVKDONJSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
16317953, 23414456, 42313638, 77365611, 92721417, 99436978, 103483726, 104069124, 124490329, 124756986, 125163791, 126619161, 126661321, 126661731, 126730839, 131480673, 134343564, 134964399, 135252957, 135727386, 136367284, 136368025, 136377882, 136920387, 137276004, 141643704, 144115752, 152059805, 152088878, 152258181, 152344141, 160647017, 162011436, 162029696, 162110616, 162200058, 164041879, 164775472, 170500439, 174475086, 174539891, 177748734, 178102299, 180404088, 184816398, 188899522, 198948130, 223573483, 223677759, 223705289
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Target and Pathway | |||||
Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | Modulator | [1572591] | |
NetPath Pathway | IL2 Signaling Pathway | ||||
PANTHER Pathway | Angiogenesis | ||||
VEGF signaling pathway | |||||
Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
Beta3 integrin cell surface interactions | |||||
Signaling events mediated by TCPTP | |||||
SHP2 signaling | |||||
S1P1 pathway | |||||
VEGF and VEGFR signaling network | |||||
Integrins in angiogenesis | |||||
Signaling events mediated by VEGFR1 and VEGFR2 | |||||
Notch-mediated HES/HEY network | |||||
References | |||||
Ref 523016 | ClinicalTrials.gov (NCT01108705) Comparison of Brivanib and Best Supportive Care (BSC) With Placebo and BSC for Treatment of Liver Cancer in Asian Patients Who Have Failed Sorafenib Treatment. U.S. National Institutes of Health. | ||||
Ref 541015 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5671). |
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