Drug General Information
Drug ID	D0I3EY
Former ID	DNC003228
Drug Name	5-phenyl-1H-indazol-3-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551374]
Structure		Download 2D MOL 3D MOL
Formula	C13H11N3
Canonical SMILES	C1=CC=C(C=C1)C2=CC3=C(C=C2)NN=C3N
InChI	1S/C13H11N3/c14-13-11-8-10(6-7-12(11)15-16-13)9-4-2-1-3-5-9/h1-8H,(H3,14,15,16)
InChIKey	ZCUSNQPYUNLATP-UHFFFAOYSA-N
PubChem Compound ID	11492186
PubChem Substance ID	16594036, 23625324, 42571050, 56261066, 76949768, 87557769, 99443632, 103608350, 104106953, 139915744, 160968246, 180410798, 229383615, 244266643, 246910019
Target and Pathway
Target(s)	Tyrosine-protein kinase JAK2	Target Info	Inhibitor	[551374]
KEGG Pathway	Chemokine signaling pathway
	PI3K-Akt signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Jak-STAT signaling pathway
	Cholinergic synapse
	Prolactin signaling pathway
	Adipocytokine signaling pathway
	Leishmaniasis
	Toxoplasmosis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infection
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interferon-gamma signaling pathway
	JAK/STAT signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	ErbB4 signaling events
	GMCSF-mediated signaling events
	IL4-mediated signaling events
	IL27-mediated signaling events
	Signaling events mediated by PTP1B
	IL12-mediated signaling events
	S1P3 pathway
	SHP2 signaling
	CXCR4-mediated signaling events
	IL5-mediated signaling events
	IFN-gamma pathway
	ErbB2/ErbB3 signaling events
	IL3-mediated signaling events
	IL6-mediated signaling events
	PDGFR-beta signaling pathway
	IL23-mediated signaling events
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	Notch-mediated HES/HEY network
Reactome	Interleukin-6 signaling
	MAPK3 (ERK1) activation
	MAPK1 (ERK2) activation
	GPVI-mediated activation cascade
	Prolactin receptor signaling
	RMTs methylate histone arginines
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF activation
	RAF/MAP kinase cascade
	Interferon gamma signaling
	Regulation of IFNG signaling
	Interleukin receptor SHC signaling
	Growth hormone receptor signaling
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Type II interferon signaling (IFNG)
	Notch Signaling Pathway
	EPO Receptor Signaling
	EGF/EGFR Signaling Pathway
	IL-4 Signaling Pathway
	IL-6 signaling pathway
	Kit receptor signaling pathway
	IL-3 Signaling Pathway
	Mesodermal Commitment Pathway
	Interleukin-2 signaling
	Signaling by SCF-KIT
	Prolactin receptor signaling
	Growth hormone receptor signaling
	JAK/STAT
	BDNF signaling pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TSLP Signaling Pathway
	IL17 signaling pathway
	Leptin signaling pathway
	TSH signaling pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interferon gamma signaling
	Factors involved in megakaryocyte development and platelet production
	IL-5 Signaling Pathway
References
Ref 551374	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551374	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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