Drug Information

Drug General Information
Drug ID
D0I5TV
Former ID
DIB019700
Drug Name
dATPalphaS
Synonyms
dATPalphaS
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539067]
Structure
Download
2D MOL
Formula
C10H16N5O11P3S
InChI
InChI=1S/C10H16N5O11P3S/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(24-7)2-23-29(22,30)26-28(20,21)25-27(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,30)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+,29?/m0/s1
InChIKey
CCPIKNHZOWQALM-DLQJRSQOSA-N
PubChem Compound ID
196416
PubChem Substance ID
3722354, 10262151, 14884637, 33516551, 50742326, 57398546, 113462929, 117643422, 127605473, 135173086, 135227102, 135651465, 174491313, 226575737
Target and Pathway
Target(s) P2Y purinoceptor 1 Target Info Agonist [534388]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539067(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1715).
Ref 534388An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44.

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