Drug Information

Drug General Information
Drug ID
D0J1SX
Former ID
DIB018614
Drug Name
4alpha-PDH
Synonyms
4alpha-phorbol 12,13-dihexanoate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467449]
Structure
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2D MOL
Formula
C32H48O8
InChI
InChI=1S/C32H48O8/c1-7-9-11-13-24(34)39-28-20(4)31(38)22(16-21(18-33)17-30(37)23(31)15-19(3)27(30)36)26-29(5,6)32(26,28)40-25(35)14-12-10-8-2/h15-16,20,22-23,26,28,33,37-38H,7-14,17-18H2,1-6H3/t20-,22+,23-,26-,28-,30+,31-,32-/m1/s1
InChIKey
XGPRSRGBAHBMAF-QYSBVNMQSA-N
PubChem Compound ID
42638006
PubChem Substance ID
81077239, 89914492, 103651854, 104120074, 178100928
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily V member 4 Target Info Activator [530069]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 467449(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4105).
Ref 530069Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study. J Med Chem. 2009 May 14;52(9):2933-9.

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