Drug Information

Drug General Information
Drug ID
D0J7MM
Former ID
DNC006949
Drug Name
ADS-103316
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528581]
Structure
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2D MOL

3D MOL
Formula
C22H24N4O3
Canonical SMILES
CC1=NC(=NC2=C1C=C(C=C2)NC(=O)COC3=CC=C(C=C3)OC)N4CCCC4
InChI
1S/C22H24N4O3/c1-15-19-13-16(5-10-20(19)25-22(23-15)26-11-3-4-12-26)24-21(27)14-29-18-8-6-17(28-2)7-9-18/h5-10,13H,3-4,11-12,14H2,1-2H3,(H,24,27)
InChIKey
YXNSFDJSYOVION-UHFFFAOYSA-N
PubChem Compound ID
11440762
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Inhibitor [528581]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.

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